3 1 0
chapter 16
Carbohydrate Metabolism III: Glycoproteins, Glycolipids, GPI Anchors, Proteoglycans, and Peptidoglycans
Blood Groups
A
Side Chain Structure
GalNAcal -3Galß-
|a 1 -2
Fuc
Gala1-3Galß-
|a 1 -2
Fuc
HorO
T
Sialyl-T
Tn
Sialyi-Tn
(SA-Tn)
Forssman
S«(Cad)
i
I
Le*
Le»
Le*
(SSEA-1)
Le»
Sialy-Le*
(SA-Le»
Sialy-Le*
(SA-Le*i
Sialyl-dimeric Le*
(SA-dimeric Le*1
Galß-
|a1-2
Fuc
Galß1-3GalNAca-
SAa2-3Galß 1 -3GalN Aca-
GalNAca-
SAa2-6GalNAca-
GalNAca1-3GalNAcß1-3Gal-
GalNAcß1-4(SAa2-3)Galß-
Gal1-4GlcNAcß1-3Galß-
Galß1-4GlcNAc
|ß1-6
Galß1-4GlcNAcß1-3Galß-
Type 1 chain
Type 2 chain
Galß1-3GlcNAcßl-3Gal-
|a1-4
Fuc
Gatß1-3GlcNAcß1-3Gal-
|o1-2
|a1-4
Fuc
Fuc
Gaiß1-4GlcNAcß1-3Gal-
|a1-3
Fuc
Galß1-4GlcNAcß1-3Gal-
|a1-2
|a1-3
Fuc
Fuc
SAo2-3Galß1-3GlcNAcß1-3Gal-
|a1-4
Fuc
SAa2-3Galß1-4GlcNAcß1-3Gal-
|a1-3
Fuc
SAa2-3Galß1-4GlcNAcß1-3Galßl-4GlcNAc-
|a1-3
|o1-3
Fuc
Fuc
FIGURE 16-2
Carbohydrate blood group and tissue antigens. [Reproduced with permission from I. Brockhausen,
Clinical aspects of glycoprotein biosynthesis.
C rit. Rev. C lin. Lab. Sci.
3 0 :7 0
(1993).]
B ra n c h e s of
m u ltia n te n n a ry o lig o s a c c h a rid e s
G Ic N A c -tra n s fe ra s e
bi
tri
tri*
te tra
p e n ta b is e c te d
V
G lc N A c ß
6
+
+
+
V I
G Ic N A c ß 4 -------M a n a
6
+
II
G lc N A c ß 2 /
/
\
+
+
+
+
+
III
G Ic N A c ß 4 M a n ß 4 G lc N A c ß 4 G !c N A c ß -R
+
IV
G Ic N A c ß 4 .
1
+
+
+
I
G Ic N A c ß 2 ------- M an<x3
+
+
+
+
+
FIGURE 16-3
Bisected penta-antennary oligosaccharide found in hen ovomucoid. The GlcNAc-transferases (named with
Roman numerals) are responsible for the addition of the GlcNAc residues that initiate antennae. The branches
present in various multiantennary and bisected N-glycans are indicated. [Reproduced with permission from
I. Brockhausen, Clinical aspects of glycoprotein biosynthesis.
C rit. Rev. C lin. Lab. Sci.
3 0 :6 8
(1993).]
